Surgical Principles: Skin/Wound Preparation

Povidone Iodine (Betadine)

• Mechanism:
  • Iodine – Oxidizes
  • Povidone – Prevents Systemic Absorption and Toxicity
• No Dry Time Required

Chlorhexidine Gluconate (CHG)

• Mechanism: Destabilizes Membrane
• Better Prevention of Surgical Site Infection in Clean & Clean-Contaminated Surgery
  • Not Inactivated by Blood/Serum
• Contraindications:
  • Open Wounds (Systemic Toxicity)
  • Use on Face (Ototoxic & Cornea Damage)
• “Chloraprep” by BD – 2% CHG & 70% Isopropyl Alcohol
  • Flammable Risk from Alcohol – Requires 3 Minute Dry Time